Archive | August 2013

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Crystallography for beginners – part 6b – what to do when the protein doesn’t crystallize? Lysine Methylation

In the previous post I have discussed how limited proteolysis aids in protein’s fold boundaries determination and identification of the minimal crystallizeable fragments or domains. An important factor controlling protein crystallization is surface contact arrays between one molecule to another. Under most circumstances crystallographers can’t know which residue participates in surface interaction and whether this modification […]